Bibliography for Melatonin
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The purpose of this clinical trial on possible effects of nocturnal MEL administration in perimenopausal women was to find if MEL by itself modifies levels of hormones and produces changes of any kind, independently of age (42-62 years of age) and the stage of the menstrual cycle. It is accepted that a close link exists between the pineal gland, MEL, and human reproduction and that a relationship exists between adenohypophyseal and steroid hormones and MEL during the ovarian cycle, perimenopause, and menopause. Subjects took a daily dose of 3 mg synthetic melatonin or a placebo for 6 months. Levels of melatonin were determined from five daily saliva samples taken at fixed times. Hormone levels were determined from blood samples three times over the 6-month period. Our results indicate that a cause-effect relationship between the decline of nocturnal levels of MEL and onset of menopause may exist. The follow up controls show that MEL abrogates hormonal, menopause-related neurovegetative disturbances and restores menstrual cyclicity and fertility in perimenopausal or menopausal women. At present we assert that the six-month treatment with MEL produced a remarkable and highly significant improvement of thyroid function, positive changes of gonadotropins towards more juvenile levels, and abrogation of menopause-related depression.
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Book Reviews Russel J. Reiter Pineal Research Reviews, vol. 1 Alan R. Liss, New York 1983 XI + 276 pp.; E43.00 ISBN 0-8451-3600-3 This volume is the first one of a new series which is promised a great future. For the scientists working in the field of the pineal gland, it will be of great interest, as it contains review articles written by experts. The first volume contains 6 articles of a long...
متن کاملP-169: Melatonin and Fertility
Background: Melatonin is a hormone secreted by the pineal gland in the brain. It helps regulate other hormones and maintains the body’s daily rhythm, telling us when to fall asleep and when to wake up. Ever since we developed electricity and the lightbulb, we have been decreasing our body’s secretions of melatonin by being exposed to bright light after it is dark. Jet lag, shift work and poor v...
متن کاملMelatonin: A therapeutic potential for the neurohormone in gallbladder disorders
In humans, N-acetyl-5-methoxytryptamine (melatonin), a neurohormone widely found in plants and animal sources, is synthesized from serotonin primarily by the pineal gland. However, it it is also produced in a number of other areas, e.g. the gastrointestinal tract. Melatonin regulates various biological and physiologic body functions and its role in the regulation of circadian rhythms, particula...
متن کاملO-13: Exogen Melatonin Protects SpermatogenicCells from Apoptosis in Mouse underChemotherapy
Background: The aim of this study was to investigate the possible protective role of melatonin on the apoptosis of germ cells in chemotherapy-induced spermiotoxicity. Materials and Methods: Male adult NMRI mice were divided into four groups. Then each group were divided into two subgroups of a and b. Group 1 (control): mice received vehicle (ethanol 1%) for 5 days; Group2 (Busulfan): mice recei...
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